In May 2015, the MURDOCK Study provided 150 anonymous DNA samples to assist in the screening and recruitment of participants for a male fertility study run by the UNC Nutrition Research Institute. The samples were analyzed for the presence of a particular genetic variant, resulting in the identification of 13 individuals eligible for the study. Subsequently, 87 additional MURDOCK Study samples were evaluated, yielding 7 men with the genetic marker being studied.
Two MURDOCK Study participants eventually joined the UNC-NRI study, increasing enrollment to five individuals. Investigators are seeking a total enrollment of 10 men.
Principal Investigator: Steven H. Zeisel, MD, PhD, is the Kenan Distinguished Professor of Nutrition and Pediatrics at the University of North Carolina Chapel Hill Nutrition Research Institute (NRI) on the North Carolina Research Campus in Kannapolis.
Goal: The purpose of the research is to determine whether a common genetic variation in men causes abnormal sperm function and whether treatment with a dietary supplement (betaine) can correct this problem.
Eligibility Requirements: Men between the ages of 18 and 60 are screened for eligibility.
Study Requirements: All research procedures will be conducted at the UNC Nutrition Research Institute (NRI) at the North Carolina Research Campus (500 Laureate Way, Kannapolis, NC 28081). Prior to enrolling in the research study, you will be asked to come to the NRI in Kannapolis, NC for approximately 30 minutes. We will ask you some questions about fertility, and you will be asked to provide a blood sample to ensure that you may safely participate. You will also be asked to complete a food questionnaire. If you are eligible, the research study will last for approximately eleven weeks and consists of blood and sperm studies on day 0, day 10, day 30, day 50 and again on day 75. Study subjects will be asked to take capsules containing a dietary supplement.
Compensation: Participants will receive $600 upon completion of the research study.
To volunteer for this research study, please contact 704-250-5035 or Sperm_Study@unc.edu