Osteoarthritis

Study Goals and Findings

Osteoarthritis (OA) is the most common form of arthritis and disability in the Western world. It affects 85% of the population 75 years of age and older and is often considered an inevitable result of aging. Despite the prevalence of osteoarthritis, there are few compelling predictors of disease progression, greatly inhibiting the development of new treatments.

Horizon 1 investigators sought to establish diagnostic tools to effectively predict progression of osteoarthritis, leading to earlier interventions and successful treatment before onset of disability. The research team applied mass spectroscopy to identify new protein markers as diagnostic and predictive measures of knee osteoarthritis development and progression. Fractal signature analysis (FSA), a type of X-ray image analysis, has been determined to be another predictor of knee OA progression. Through clinical application of these detection techniques, doctors may be able to reduce both the prevalence and severity of osteoarthritis.

Meet the Principal Investigator
virginia byers kraus
Virginia Byers Kraus, MD, PhD
Related Publications and Abstracts
  1. Kraus VB, Feng S, Wang S, White S, Ainslie M, Hellio Le Graverand M, Brett A, Eckstein F, Charles HC. Subchondrial Bone Trabecular Integrity Predicts and Changes Concurrently with Radiographic and MRI Determined Osteoarthritis Progression. Arthritis Rheum. 2013;65(7):1812–21. DOI 10.1002/art.37970
  2. Kraus VB, Birmingham J, Stabler T, Feng S, Taylor DC, Moorman CT 3rd, Garrett WE, Toth A. Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254). Osteoarthritis Cartilage. 2012; 20: 271-278. 
  3. Catterall JB, Hsueh MF, Stabler TV, Feng S, McCudden CF, Bolognesi M, Zuru R, Jordan JM, Renner JB, Kraus VB. Protein Modification by Deamidation Indicates Variations in Joint Extracellular Martrix Turnover. J Biol Chem. 2012 Feb. 10;287(7):4640-51. Epub 2011 Dec 16 PubMed: 22179616, PMC3281605
  4. Kraus VB, Feng S, Wang S, White S, Ainslie M, Hellio Le Graverand M, Brett A, Charles HC. 2010. Subchondral Bone Trabecular Integrity Predicts and Changes Concurrently with Osteoarthritis ProgressionOsteoarthritis & Cartilage. 18(2):S28.
  5. Kraus, VB, S Feng, SC Wang, S White, M Ainslie, A Brett, A Holmes, HC Charles. 2009.Trabecular morphometry by fractal signal analysis is a novel marker of osteoarthritis progression.Arthritis Rheum. 60(12): 3711-3722.

 

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